[1]张芳,徐永红,荆雪,等.急性胰腺炎病人维生素代谢变化及其影响因素[J].青岛大学医学院学报,2017,53(03):320-323.[doi:10.13361/j.qdyxy.201703019]
 ZHANG Fang,XU Yonghong,JING Xue,et al.CHANGES IN METABOLISM OF VITAMINS AND RELATED INFLUENCING FACTORS IN PATIENTS WITH ACUTE PANCREATITIS[J].Acta Aacademiae Medicinae Qingdao,2017,53(03):320-323.[doi:10.13361/j.qdyxy.201703019]
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急性胰腺炎病人维生素代谢变化及其影响因素()
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《青岛大学医学院学报》[ISSN:1672-4488/CN:37-1356/R]

卷:
第53卷
期数:
2017年03期
页码:
320-323
栏目:
出版日期:
2017-08-07

文章信息/Info

Title:
CHANGES IN METABOLISM OF VITAMINS AND RELATED INFLUENCING FACTORS IN PATIENTS WITH ACUTE PANCREATITIS
文章编号:
1672-4488(2017)03-0320-04
作者:
张芳徐永红荆雪李新华
青岛大学附属医院消化内科,山东 青岛 266003
Author(s):
ZHANG Fang XU Yonghong JING Xue LI Xinhua
Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
关键词:
胰腺炎急性坏死性维生素类代谢
Keywords:
pancreatitis acute necrotizing vitamins metabolism
分类号:
R576
DOI:
10.13361/j.qdyxy.201703019
文献标志码:
A
摘要:
目的 探讨急性胰腺炎(AP)病人维生素代谢变化及其影响因素。
方法 AP病人111例,其中轻症AP(MAP)39例,中重症AP(MSAP)38例,重症AP(SAP)34例,静脉应用常规推荐量维生素。检测病人血清维生素A(VA)、VB1、VB2、VB6、VB9、VB12、VC、VD、VE的浓度,计算AP床旁严重程度指数(BISAP)评分,并分析其影响因素。以37例健康体检者作为对照组。
结果 AP病人血清VB1、VB2、VB6、VB9、VB12浓度与对照组比较差异无统计学意义(P>0.05);VA、VC、VD、VE浓度低于对照组,差异有统计学意义(F=21.311~111.964,P<0.05)。SAP组VA浓度较MAP组下降,MAP组、MSAP组与SAP组相比,VC、VD、VE浓度明显下降,差异均有统计学意义(F=21.311~111.964,P<0.05)。AP病人VA、VC、VD、VE浓度与BISAP评分负相关(r=-0.668~-0.562,P<0.05),其中VC浓度变化还与采血前禁食天数、年龄有关。
结论 AP病人病情越严重,血清VA、VC、VD、VE浓度下降越显著;SAP病人静脉补充常规推荐量的VA、VC、VD、VE不能满足发病时机体需要量。
Abstract:
Objective  To investigate the changes in metabolism of vitamins and related influencing factors in patients with acute pancreatitis (AP).
Methods  A total of 111 patients diagnosed with AP were enrolled in the study. All the patients were divided into three groups according to the severity of AP: mild acute pancreatitis (MAP) (n=39), moderate-severe acute pancreatitis (MSAP) (n=38), and severe acute pancreatitis (SAP) (n=34). All the patients were given conventionally recommended amounts of vitamins by intravenous supplementation. The levels of serum vitamins (vitamins A, B1, B2, B6, B9, B12, C, D, and E) were measured, the Bedside Index for Severity in Acute Pancreatitis (BISAP) scores were calculated, and the factors related to metabolism of vitamins were determined. Thirty-seven healthy subjects were used as controls.
Results  There were no significant differences in levels of vitamins B1, B2, B6, B9, and B12 between the MAP, MSAP, and SAP groups and the control group (P>0.05). Compared with the control group, the MAP, MSAP, and SAP groups had significantly lower levels of vitamins A, C, D and E (F=21.311-111.964, P<0.05). The SAP group had a significantly reduced vitamin A level than the MAP group; compared with the SAP group, the MAP and MSAP groups had significant reductions in levels of vitamins C, D, and E (F=21.311-111.964,P<0.05). In patients with AP, serum vitamins A, C, D and E levels were negatively correlated with the BISAP score (r=-0.668--0.562;P<0.05). In addition, vitamin C level was also correlated with the length of fasting before a blood test and age.
Conclusion  The patients with different severities of AP show significantly different levels of serum vitamins A, C, D and E,and the reduction in levels of vitamins A, C, D and E is positively correlated with the severity of AP. Intravenous supplementation of conventionally recommended amounts of vitamins A, C, D and E cannot meet the body’s need in patients with SAP.
更新日期/Last Update: 2017-08-13