[1]黄飞,姜祥智,王华青.不同药物对卒中后失语伴抑郁病人的治疗效果[J].青岛大学医学院学报,2017,53(03):333-335.[doi:10.13361/j.qdyxy.201703023]
 HUANG Fei,JIANG Xiangzhi,WANG Huaqing.CLINICAL EFFECTS OF DIFFERENT DRUGS IN TREATMENT OF POST-STROKE APHASIA COMPLICATED BY DEPRESSION[J].Acta Aacademiae Medicinae Qingdao,2017,53(03):333-335.[doi:10.13361/j.qdyxy.201703023]
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不同药物对卒中后失语伴抑郁病人的治疗效果()
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《青岛大学医学院学报》[ISSN:1672-4488/CN:37-1356/R]

卷:
第53卷
期数:
2017年03期
页码:
333-335
栏目:
出版日期:
2017-08-07

文章信息/Info

Title:
CLINICAL EFFECTS OF DIFFERENT DRUGS IN TREATMENT OF POST-STROKE APHASIA COMPLICATED BY DEPRESSION
文章编号:
1672-4488(2017)03-0333-03
作者:
黄飞1姜祥智1王华青2
1 青岛市精神卫生中心精神科,山东 青岛 266034; 2 莘县人民医院神经内科
Author(s):
HUANG Fei JIANG Xiangzhi WANG Huaqing
Psychiatric Ward of Qingdao Mental Health Center, Qingdao 266034, China
关键词:
卒中失语抑郁药物疗法治疗结果
Keywords:
stroke aphasia depression drug therapy treatment outcome
分类号:
R767.64;R749.42
DOI:
10.13361/j.qdyxy.201703023
文献标志码:
A
摘要:
目的 比较不同药物对早期卒中后失语伴抑郁病人的治疗效果。
方法 选择发病1个月内的卒中后失语伴抑郁病人150例,按治疗药物分为4组,对照组40例,美金刚组35例,溴隐亭组38例,艾司西酞普兰组37例,对照组仅给予常规治疗,其他组给予常规治疗及相应药物治疗,共治疗4周。分别于治疗前、治疗第4周末采用汉语失语症成套测验(ABC)量表及中文版卒中后失语病人抑郁问卷(SADQ)对病人进行评估。
结果 经过4周治疗,美金刚组和艾司西酞普兰组听理解及阅读理解评分显著高于治疗前(t=2.160~2.960,P<0.05),艾司西酞普兰组命名评分显著高于治疗前(t=2.417,P<0.05);艾司西酞普兰组SADQ评分显著低于治疗前(t=3.034,P<0.01)。
结论 早期卒中后失语伴抑郁病人采用常规治疗联合艾司西酞普兰治疗可促进命名、听理解、阅读能力和抑郁症状的改善,采用常规治疗联合美金刚治疗可促进听理解和阅读能力的改善。
Abstract:
Objective  To investigate the clinical effects of different drugs in the treatment of early post-stroke aphasia complicated by depression.
Methods  A total of 150 patients with post-stroke aphasia complicated by depression within one month after disease onset were enrolled, and according to the drug used for treatment, they were divided into control group with 40 patients, memantine group with 35 patients, bromocriptine group with 38 patients, and escitalopram group with 37 patients. The patients in the control group were given conventional treatment alone, while those in the other groups were given conventional treatment and corresponding drug treatment. The course of treatment was 4 weeks for all groups. The Aphasia Battery of Chinese scale and the Chinese version of Stroke Aphasic Depression Questionnaire (SADQ) were used for evaluation before treatment and at the end of week 4 of treatment.
Results  After the 4 weeks of treatment, the memantine group and the escitalopram group had significant increases in the scores of listening comprehension and reading comprehension (t=2.160-2.960,P<0.05). The escitalopram group had a significant increase in the naming score (t=2.417,P<0.05) and a significant reduction in SADQ score (t=3.034,P<0.01) after treatment.
Conclusion  In patients with early post-stroke aphasia complicated by depression, conventional treatment combined with escitalopram can improve naming ability, listening comprehension, and reading comprehension and promote the improvement in depressive symptoms, and conventional treatment combined with memantine can only promote the improvement in listening and reading comprehension.
更新日期/Last Update: 2017-08-13