[1]罗波,张劲峰.盐酸坦洛新缓释片并吲哚美辛栓剂预防经尿道前列腺切除术后膀胱痉挛的效果[J].青岛大学医学院学报,2017,53(03):349-352.[doi:10.13361/j.qdyxy.201703029]
 LUO Bo,ZHANG Jinfeng.CLINICAL EFFECT OF TAMSULOSIN HYDROCHLORIDE SUSTAINED-RELEASE TABLETS COMBINED WITH INDOMETHACIN SUPPOSITORIES IN PREVENTING BLADDER SPASM AFTER TRANSURETHRAL RESECTION OF THE PROSTATE[J].Acta Aacademiae Medicinae Qingdao,2017,53(03):349-352.[doi:10.13361/j.qdyxy.201703029]
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盐酸坦洛新缓释片并吲哚美辛栓剂预防经尿道前列腺切除术后膀胱痉挛的效果()
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《青岛大学医学院学报》[ISSN:1672-4488/CN:37-1356/R]

卷:
第53卷
期数:
2017年03期
页码:
349-352
栏目:
出版日期:
2017-08-07

文章信息/Info

Title:
CLINICAL EFFECT OF TAMSULOSIN HYDROCHLORIDE SUSTAINED-RELEASE TABLETS COMBINED WITH INDOMETHACIN SUPPOSITORIES IN PREVENTING BLADDER SPASM AFTER TRANSURETHRAL RESECTION OF THE PROSTATE
文章编号:
1672-4488(2017)03-0349-04
作者:
罗波张劲峰
青岛大学松山医院泌尿外科,山东 青岛 266021
Author(s):
LUO Bo ZHANG Jinfeng
Department of Urology, Songshan Hospital, Qingdao University, Qingdao 266021, China
关键词:
坦洛新吲哚美辛膀胱痉挛前列腺切除术治疗结果重复测量设计方差分析
Keywords:
tamsulosin indomethacin urinary bladder spasm prostatectomy treatment outcome varianle analysis of repeated measurement design
分类号:
R697.32;R694
DOI:
10.13361/j.qdyxy.201703029
文献标志码:
A
摘要:
目的 探讨盐酸坦洛新缓释片联合吲哚美辛栓剂预防经尿道前列腺切除术后膀胱痉挛的临床效果。
方法 将入选的300例经尿道前列腺切除术后病人随机分为5组,每组60例。A组术后不应用盐酸坦洛新缓释片及吲哚美辛栓剂;B组于术后即刻肛门置入吲哚美辛栓剂100 mg,每12 h给药1次;C组于术后麻醉清醒后口服盐酸坦洛新缓释片0.2 mg/d;D组于术后即刻肛门置入吲哚美辛栓剂100 mg,每12 h给药1次,麻醉清醒后口服盐酸坦洛新缓释片0.2 mg/d;E组于术后麻醉清醒后口服酒石酸托特罗定片2 mg,每天2次。B~E组均于手术后3 d停药。
结果 D组病人术后3 d内每天膀胱痉挛次数、膀胱痉挛持续时间、疼痛程度以及术后膀胱冲洗液转清时间显著低于A、B、C组(F=96.07~999.55,P<0.05),但与E组比较差异无统计学意义(P>0.05)。D组病人术后拔管时间早于其他组,差异有统计学意义(F=33.58,P<0.05)。D组病人均耐受性良好,无不良反应;E组24例病人有不同程度不良反应。
结论 盐酸坦洛新缓释片联合吲哚美辛栓剂预防经尿道前列腺切除术后膀胱痉挛安全有效,值得推广。
Abstract:
Objective  To investigate the clinical effect of tamsulosin hydrochloride sustained-release tablets combined with indomethacin suppositories in preventing bladder spasm after transurethral resection of the prostate (TURP).
Methods  A total of 300 patients who underwent TURP were enrolled and randomly divided into groups A, B, C, D, and E, with 60 patients in each group. The patients in group A were not given tamsulosin hydrochloride sustained-release tablets or indomethacin suppositories after surgery; the patients in group B were given indomethacin suppositories 100 mg once every 12 h immediately after surgery; the patients in group C were given oral tamsulosin hydrochloride sustained-release tablets 0.2 mg/d after anesthetic awareness; the patients in group D were given indomethacin suppositories 100 mg once every 12 h immediately after surgery and oral tamsulosin hydrochloride sustained-release tablets 0.2 mg/d after anesthetic awareness; the patients in group E were given oral tolterodine tartrate tablets 2 mg twice a day after anesthetic awareness. The drugs were stopped at 3 days after surgery for groups B, C, D, and E.
Results  Compared with groups A, B, and C, group D had a significantly lower number of daily bladder spasms, a significantly shorter duration of bladder spasms, and a significantly lower degree of pain within 3 days after surgery, as well as a significantly shorter time to bladder perfusion clearance (F=96.07-999.55,P<0.05), while there were no significant differences in the above indices between group D and group E (P>0.05). Group B had a significantly earlier postoperative extubation time than the other groups (F=33.58,P<0.05). The patients in group D were well tolerant and did not experience any adverse reaction, while 24 patients in group E experienced varying degrees of adverse reactions.
Conclusion  Tamsulosin hydrochloride sustained-release tablets combined with indometacin suppositories is safe and effective in preventing bladder spasm after TURP and therefore, it holds promise for clinical application.
更新日期/Last Update: 2017-08-13