[1]冯燕,王庆法,赵世华,等.初诊2型糖尿病血清维生素D和AGEs变化及意义[J].青岛大学学报(医学版),2017,53(06):644-648.[doi:10.13361/j.qdyxy.201706004]
 FENG Yan,WANG Qingfa,ZHAO Shihua,et al.CHANGES IN SERUM LEVELS OF 25-HYDROXYVITAMIN D AND ADVANCED GLYCATION END PRODUCTS IN PATIENTS WITH AN INITIAL DIAGNOSIS OF TYPE 2 DIABETES AND THEIR CLINICAL SIGNIFICANCE[J].JOURNAL OF QINGDAO UNIVERSITY (MEDICAL SCIENCES),2017,53(06):644-648.[doi:10.13361/j.qdyxy.201706004]
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初诊2型糖尿病血清维生素D和AGEs变化及意义()
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《青岛大学学报(医学版)》[ISSN:2096-5532/CN:37-1217/R]

卷:
第53卷
期数:
2017年06期
页码:
644-648
栏目:
出版日期:
2018-03-21

文章信息/Info

Title:
CHANGES IN SERUM LEVELS OF 25-HYDROXYVITAMIN D AND ADVANCED GLYCATION END PRODUCTS IN PATIENTS WITH AN INITIAL DIAGNOSIS OF TYPE 2 DIABETES AND THEIR CLINICAL SIGNIFICANCE
文章编号:
1672-4488(2017)06-0644-05
作者:
冯燕1王庆法1赵世华2赵婷2王娈2王颜刚2
1 潍坊市益都中心医院儿内科,山东 青州 262500; 2 青岛大学附属医院内分泌科
Author(s):
FENG Yan WANG Qingfa ZHAO Shihua ZHAO Ting WANG Luan WANG Yan′gang
Department of Paediatrics, Weifang Yidu Central Hospital, Qingzhou 262500, China
关键词:
糖尿病2型胰岛素抗药性骨化醇类高级糖基化终产物特异性受体胰岛素分泌细胞
Keywords:
diabetes mellitus type 2 insulin resistance ergocalciferols advanced glycosylation end product-specific receptor insulin-secreting cells
分类号:
R587.1
DOI:
10.13361/j.qdyxy.201706004
文献标志码:
A
摘要:
目的 观察初诊2型糖尿病病人体内血清25-羟维生素D(25-OH-D)和晚期糖基化终末产物(AGEs)含量变化,分析其变化与胰岛素抵抗和胰岛β细胞早相分泌功能的关系。
方法 选取初诊2型糖尿病病人60例为观察组,另选择同期参加门诊体检的40名健康人作为正常对照组。分别测定两组血清25-OH-D、AGEs、白细胞介素-1β(IL-1β)、空腹血糖、血脂和糖化血红蛋白(HbA1c)等指标,并同期进行精氨酸试验。两因素间关系采用Pearson相关分析,多个变量间的分析采用多元逐步回归分析。
结果 与对照组比较,观察组25-OH-D含量明显降低,而AGEs、IL-1β明显增高,差异均有统计学意义(t=-9.276~4.430,P<0.01)。相关分析显示,25-OH-D与胰岛素第一时相峰值倍数呈正相关(r=0.453,P<0.01),而与稳态模型胰岛素抵抗指数(HOMA-IR)、AGEs和IL-1β呈负相关(r=-0.425~-0.315,P<0.01)。多元逐步回归分析显示,校正性别、年龄、血脂、血压、HbA1c和IL-1β后,胰岛素第一时相峰值倍数与25-OH-D呈显著正相关(t=5.028,P<0.01),与AGEs呈显著负相关(t=-2.933,P<0.01);HOMA-IR与25-OH-D呈显著负相关(t=-2.234,P<0.05),与AGEs呈显著正相关(t=11.513,P<0.01)。
结论 初诊2型糖尿病病人体内维生素D水平降低,而AGEs水平升高,可能与胰岛素抵抗和胰岛β细胞早相分泌功能下降相关。
Abstract:
Objective  To investigate the changes in the serum levels of 25-hydroxyvitamin D(25-OH-D) and advanced glycation end products (AGEs) in patients with an initial diagnosis of type 2 diabetes and their association with insulin resistance and early-phase secretion function of pancreatic β cells.
Methods  A total of 60 patients with an initial diagnosis of type 2 diabetes were enrolled as observation group, and 40 healthy persons who underwent physical examination were enrolled as normal control group. Related indices were measured for both groups, including serum 25-OH-D, AGEs, interleukin-1β (IL-1β), fasting blood glucose, blood lipids, and HbA1c, and the arginine test was also performed. A Pearson correlation analysis was performed to investigate the correlation between two factors, and a multiple stepwise regression analysis was performed for multiple variables.
Results  Compared with the normal control group, the observation group had a significant reduction in serum 25-OH-D level and significant increases in the serum levels of AGEs and IL-1β (t=-9.276 to 4.430,P<0.01). The correlation analysis showed that 25-OH-D was positively correlated with the insulin secretion peak in the first phase (r=0.453,P<0.01) and negatively correlated with homeostasis model assessment of insulin resistance (HOMA-IR), AGEs, and IL-1β (r=-0.425 to-0.315,P<0.01). The multiple stepwise regression analysis showed that after adjustment for sex, age, blood lipids, blood pressure, HbA1c, and IL-1β, insulin secretion peak was positively correlated with 25-OH-D (t=5.028,P<0.01) and negatively correlated with AGEs (t=-2.933,P<0.01); HOMA-IR was negatively correlated with 25-OH-D (t=-2.234,P<0.05) and positively correlated with AGEs (t=11.513,P<0.01).
Conclusion  Patients with an initial diagnosis of type 2 diabetes have a reduction in serum 25-OH-D and an increase in AGEs, which may be associated with insulin resistance and reduced early-phase secretion function of pancreatic β cells.
更新日期/Last Update: 2018-03-24