[1]徐诗钦,徐永红,边城,等. 急性胰腺炎后出现血糖受损或糖尿病相关因素分析[J].青岛大学学报(医学版),2018,54(03 ):291-295,301.[doi:10.11712/jms201803009]
 XU Shiqin,XU Yonghong,BIAN Cheng,et al. RELATED FACTORS FOR IMPAIRED FASTING GLUCOSE OR DIABETES MELLITUS IN PATIENTS WITH ACUTE PANCREATITIS[J].JOURNAL OF QINGDAO UNIVERSITY (MEDICAL SCIENCES),2018,54(03 ):291-295,301.[doi:10.11712/jms201803009]
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 急性胰腺炎后出现血糖受损或糖尿病相关因素分析()
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《青岛大学学报(医学版)》[ISSN:2096-5532/CN:37-1217/R]

卷:
第54卷
期数:
2018年03 期
页码:
291-295,301
栏目:
出版日期:
2018-05-29

文章信息/Info

Title:
 RELATED FACTORS FOR IMPAIRED FASTING GLUCOSE OR DIABETES MELLITUS IN PATIENTS WITH ACUTE PANCREATITIS
作者:
 徐诗钦徐永红边城武军田字彬
 青岛大学附属医院消化内科,山东 青岛 266003
Author(s):
 XU Shiqin XU Yonghong BIAN Cheng WU Jun TIAN Zibin
 Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
关键词:
 胰腺炎血糖糖尿病危险因素
Keywords:
 pancreatitis blood glucose diabetes mellitus risk factors
分类号:
R576
DOI:
10.11712/jms201803009
文献标志码:
A
摘要:
 目的 探讨急性胰腺炎(AP)病人后期空腹血糖受损(IFG)或糖尿病(DM)的发生率及其影响因素。
方法 收集788例非糖尿病或既往无血糖升高病史的AP病人,对其临床资料进行分析,随访6个月空腹血糖指标,分析AP病人后期出现IFG或DM的影响因素。
结果 单因素分析显示,性别、有无饮酒史对AP后期血糖结果无影响(P>0.05),而年龄、BMI值、疾病发作频率对血糖结果有影响(χ2=7.207~49.021,P<0.05)。随访显示,中重症(MSAP)组、重症(SAP)组IFG、DM发生率均明显高于轻症(MAP)组,差异有显著性(χ2=61.4、167.9,P<0.01);CT分级Ⅱ、Ⅲ级IFG、DM发生率明显高于Ⅰ级,差异有显著性(χ2=77.6、198.9,P<0.01)。胆固醇(TC)、三酰甘油(TG)、C反应蛋白(CRP)、血钙、入院48 h内最高血糖浓度、白细胞计数中位数水平对血糖结果有影响,差异均有显著性(χ2=20.435~240.380,H=65.724,P<0.01)。多因素分析显示,MSAP、SAP、CT严重指数评分(CTSI)≥7、TG>2.3 mmol/L、血钙<2.0 mmol/L、入院48 h最高血糖浓度>11.1 mmol/L是AP病人后期出现IFG的危险因素(OR=2.904~9.725,95%CI=1.308~31.299,P<0.05)。BMI≥24 kg/m2、CTSI≥7分、血钙<2.0 mmol/L、入院48 h最高血糖浓度>11.1 mmol/L是AP病人后期出现DM的危险因素(OR=7.645~80.582,95%CI=1.105~535.326,P<0.05)。
结论 AP病人后期出现IFG或DM与多种因素有关,对存在危险因素的AP病人,应加强血糖监测。
Abstract:
 Objective To investigate the incidence rate of impaired fasting glucose (IFG) or diabetes mellitus (DM) in patients with acute pancreatitis (AP) in the late stage and related influencing factors.
Methods A total of 788 AP patients who did not have DM or a history of elevated blood glucose were enrolled and their clinical data were analyzed. The patients were followed up to measure fasting blood glucose for 6 months, and the influencing factors for IFG or DM in the late stage in AP patients were analyzed.
Results The univariate analysis showed that sex and the presence or absence of a drinking history had no influence on blood glucose results in the late stage of AP (P>0.05), while age, body mass index (BMI), and frequency of disease attack had certain influence on blood glucose results (χ2=7.207-49.021,P<0.05). According to the follow-up results, the mode-
rate-severe acute pancreatitis (MSAP) group and the severe acute pancreatitis (SAP) group had significantly higher incidence rates of IFG and DM than the mild acute pancreatitis (MAP) group (χ2=61.4 and 167.9,P<0.01); the incidence rates of grade Ⅱ and Ⅲ IFG and DM on CT were significantly higher than those of grade Ⅰ IFG and DM (χ2=77.6 and 198.9,P<0.01). Cholesterol (TC), triglyceride (TG), C-reactive protein (CRP), blood calcium, maximum blood glucose concentration within 48 h after admission, and median leukocyte count had significant influence on blood glucose results (χ2=20.435-240.380, H=65.724,P<0.01). The multivariate analysis showed that MSAP, SAP, CT severity index (CTSI) score ≥7, TG >2.3 mmol/L, blood cal-
cium <2.0 mmol/L, and maximum blood glucose concentration >11.1 mmol/L within 48 h after admission were risk factors for IFG in the late stage of AP (OR=2.904-9.725, 95% CI=1.308-31.299,P<0.05). BMI ≥24 kg/m2, CTSI score ≥7, blood calcium <2.0 mmol/L, and maximum blood glucose concentration >11.1 mmol/L within 48 h after admission were risk factors for DM in the late stage of AP (OR=7.645-80.582,95% CI=1.105-535.326,P<0.05).
Conclusion The development of IFG or DM in AP patients in the late stage is associated with various factors, and blood glucose monitoring should be strengthened for AP patients with risk factors.
更新日期/Last Update: 2018-06-05